Sell Luo Han Guo Extract

Hypoglycemic In addition to its natural sweetening characteristic, luo han guo has exhibited antihyperglycemic effects. In rats, crude extracts of S. grosvenori and the triterpene glycosides inhibited a rise in postprandial blood glucose levels when given orally 3 minutes prior to oral administration of maltose. The suggested antihyperglycemic effect was via the inhibition of maltase. Antioxidant S. grosvenori extract and the cucurbitane glycosides mogroside IV, mogroside V, 11-oxo-mogroside V, and siamenoside I inhibited copper-mediated, low-density, lipoprotein and cell-mediated, low-density lipoprotein oxidation in a dose-dependent fashion, with 11-oxo-mogroside V as the most active component. The antioxidant, free‐radical scavenging activities of the extract and 11-oxo-mogroside V were less than those of vitamin E in the same in vivo study. Antineoplastic In vitro and animal studies suggest potential cancer chemopreventive activities of cucurbitane glycosides and related compounds from the fruit of luo han guo. An ethanol extract of S. grosvenori was evaluated for its effect on Epstein-Barr virus-early antigen (EBV-EA) activation as a method of detecting chemoprotective activity. The extract inhibited activation of EBV-EA at a level similar to or greater than the activity of beta-carotene.In a similar study, 11-oxo-mogroside V and mogroside V showed strong inhibitory effects. A 2-stage skin carcinogenesis model in mice ingesting mogroside V or 11-oxomogroside V showed delayed development and reduced numbers of papillomas at 10 and 15 weeks, respectively, compared with control group animals. Inhibitory effects of mogroside V and 11-oxo-mogroside V on another skin carcinogenesis model in mice using peroxynitrite also showed a reduction in numbers of papillomas formed and delayed papilloma development.